Sesquiterpene lactone trilobolide activates production of interferon-γ and nitric oxide

0350075 - ÚEM 2011 RIV IT eng J - Journal Article
Kmoníčková, Eva - Harmatha, Juraj - Vokáč, Karel - Kostecká, Petra - Farghali, H. - Zídek, Zdeněk
Sesquiterpene lactone trilobolide activates production of interferon-γ and nitric oxide.
Fitoterapia. Roč. 81, č. 8 (2010), s. 1213-1219. ISSN 0367-326X. E-ISSN 1873-6971
R&D Projects: GA ČR GA305/07/0061
Institutional research plan: CEZ:AV0Z50390512; CEZ:AV0Z40550506
Keywords : trilobolide * nitric oxide * sesquiterpene lactones
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 1.899, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0350075_01.pdf

Trilobolide (TB), a sesquiterpene lactone isolated from Laser trilobum is an inhibitor of sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA). We have found that upon the in vitro exposure to TB, rodent peritoneal cells and human peripheral blood mononuclear cells secrete high amounts of IFN-γ. The effect is associated with the stimulation of high output NO biosynthesis in rat cells. The effect does not seem to depend on enhanced intracellular calcium levels.
Permanent Link: http://hdl.handle.net/11104/0190168