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CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases
- 1.0350071 - ÚOCHB 2011 RIV DE eng J - Journal Article
Spáčilová, Pavla - Nauš, Petr - Pohl, Radek - Votruba, Ivan - Snášel, Jan - Zábranská, Helena - Pichová, Iva - Ameral, R. - Birkuš, G. - Cihlař, T. - Hocek, Michal
CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases.
ChemMedChem. Roč. 5, č. 8 (2010), s. 1386-1396. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : nucleosides * pronucleotides * deazapurines * cytostatics
Subject RIV: CC - Organic Chemistry
Impact factor: 3.306, year: 2010
A series of cycloSal-phosphate prodrugs of a recently described new class of nucleoside cytostatics (6-hetaryl-7-deazapurine ribonucleosides) was prepared. The in vitro cytostatic effect of the pronucleotides was compared with parent nucleoside analogues. In most cases, the activity of the pronucleotide was similar to or somewhat lower than that of the corresponding parent nucleosides.
Permanent Link: http://hdl.handle.net/11104/0190164
Number of the records: 1