Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts-Indications of novel tumor-promoting cyanotoxins?

0349719 - BÚ 2011 RIV GB eng J - Journal Article
Bláha, Luděk - Babica, Pavel - Hilscherová, Klára - Upham, B. L.
Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts-Indications of novel tumor-promoting cyanotoxins?
Toxicon. Roč. 55, č. 1 (2010), s. 126-134. ISSN 0041-0101. E-ISSN 1879-3150
R&D Projects: GA ČR GA524/08/0496
Institutional research plan: CEZ:AV0Z60050516
Keywords : liver tumor promotion * cyanobacteria * microcystin
Subject RIV: EF - Botanics
Impact factor: 2.451, year: 2010

Gap-junctional intercellular communication (GJIC) and mitogen-activated protein kinases (MAPKs), well-established biomarkers of tumor promotion, were affected by cyanobacterial extracts in in vitro experiments with rat liver epithelial cells. Since the observed effects of cyanobacterial extracts did not correlate with the content of known hepatotoxic cyanotoxins, and the pure toxins (microcystin, cylindrospermopsin, lipopolysaccharides) affected neither GJIC nor MAPKs, the effects were most likely induced by not-yet characterized chemicals of produced by cyanobacteria. These mechanisms (inhibition of GJIC, activation of MAPKs) and chemicals may thus contribute to the tumor promoting activity of toxic cyanobacteria.
Permanent Link: http://hdl.handle.net/11104/0189880