AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids

0349619 - FGÚ 2011 RIV US eng J - Journal Article
Jeleník, Tomáš - Rossmeisl, Martin - Kuda, Ondřej - Macek Jílková, Zuzana - Medříková, Daša - Kůs, Vladimír - Hensler, Michal - Janovská, Petra - Mikšík, Ivan - Baranowski, M. - Gorski, J. - Hébrard, S. - Jensen, T. E. - Flachs, Pavel - Hawley, S. - Viollet, B. - Kopecký, Jan
AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids.
Diabetes. Roč. 59, č. 11 (2010), s. 2737-2746. ISSN 0012-1797. E-ISSN 1939-327X
R&D Projects: GA ČR GAP301/10/1420; GA MŠMT(CZ) 1M0520; GA MŠMT(CZ) OC08007
Grant - others:EC(CZ) LSHM-CT-2004-005272
Institutional research plan: CEZ:AV0Z50110509
Keywords : AMPK * n-3 LC-PUFA * insulin resistance
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 8.889, year: 2010

Mice with a whole-body deletion of the alfa2 catalytic subunit of AMPK and their wild-type littermates were used for testing a hypothesis whether AMP-activated protein kinase (AMPK) has a role in the beneficial effects of n-3 LC-PUFAs. Our results show that n-3 LC-PUFA prevent hepatic insulin resistance in an AMPKalfa2-dependent manner and support the role of adiponectin and hepatic diacylglycerols in the regulation of insulin sensitivity. AMPKα2 is also essential for hypolipidemic and antisteatotic effects of n-3 LC-PUFA under insulin-stimulated conditions
Permanent Link: http://hdl.handle.net/11104/0189808