Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population

0349496 - ÚEM 2011 RIV GR eng J - Journal Article
Hlavatá, I. - Vrána, D. - Šmerhovský, Z. - Pardini, Barbara - Naccarati, Alessio - Vodička, Pavel - Novotný, J. - Mohelníková-Duchoňová, B. - Souček, P.
Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population.
Oncology Reports. Roč. 24, č. 5 (2010), s. 1347-1353. ISSN 1021-335X. E-ISSN 1791-2431
R&D Projects: GA ČR GA310/07/1430
Grant - others:GA MŠk(CZ) GAUK15109/2009; GA MZd(CZ) NS10230
Institutional research plan: CEZ:AV0Z50390512
Keywords : colorectal cancer * cytochrome P450 * polymorphism
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 1.686, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0349496_01.pdf

The glutathione S-transferase Mu-1 deletion was associated with a moderately elevated colorectal cancer risk (aOR=1.30, CI=1.01-1.68, p=0.044). Combination of glutathione Stransferase Mu-1 and ı-1 deletion was associated with a significantly higher colorectal cancer risk compared to the presence of both full-length genes (aOR=1.58, CI=1.01-2.47, p=0.044). These results provide further evidence that interaction between metabolic gene variants contributes to colorectal carcinogenesis.
Permanent Link: http://hdl.handle.net/11104/0189716