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Astrocytes in Alzheimer's Disease

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    0349472 - ÚEM 2011 RIV US eng J - Journal Article
    Verkhratsky, Alexei - Olabarria, M. - Noristani, H. N. - Yeh, C. Y. - Rodríguez Arellano, Jose Julio
    Astrocytes in Alzheimer's Disease.
    Neurotherapeutics. Roč. 7, č. 4 (2010), s. 399-412. ISSN 1933-7213. E-ISSN 1878-7479
    R&D Projects: GA ČR GA309/09/1696; GA ČR GA305/08/1384
    Institutional research plan: CEZ:AV0Z50390703
    Keywords : Astrocytes * neuroglia * neurodegeneration
    Subject RIV: FH - Neurology
    Impact factor: 6.084, year: 2010
    http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0349472_01.pdf

    In this manuscript we covered the specific involvement of astrocytes in various neurodegenerative diseases including Alzheimer's disease, Amyotrophic lateral sclerosis, Parkinson's disease and various forms of dementia. We demonstrate that early stages of neurodegenerative processes are associated with atrophy of astroglia, which causes disruptions in synaptic connectivity, disbalance in neurotransmitter homeostasis and neuronal death through increased excitotoxicity. Which at the later stages astrocytes became activated and contribute to neuro-inflammatory component of neurodegeneration.
    Permanent Link: http://hdl.handle.net/11104/0189705

     
     
Number of the records: 1  

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