Concomitant Astroglial Atrophy and Astrogliosis in a Triple Transgenic Animal Model of Alzheimer's Disease

0349469 - ÚEM 2011 RIV US eng J - Journal Article
Olabarria, M. - Noristani, H. N. - Verkhratsky, Alexei - Rodríguez Arellano, Jose Julio
Concomitant Astroglial Atrophy and Astrogliosis in a Triple Transgenic Animal Model of Alzheimer's Disease.
Glia. Roč. 58, č. 7 (2010), s. 831-838. ISSN 0894-1491. E-ISSN 1098-1136
Institutional research plan: CEZ:AV0Z50390703
Keywords : astroglia * Alzheimer's disease * hippocampus
Subject RIV: FH - Neurology
Impact factor: 5.186, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0349469_01.pdf

We monitored changes in the astroglia morphology throughout the age-dependent progression of AD, in the hippocampus of a triple transgenic mouse model of AD (3xTg-AD) that mimics the temporal progression of the human disease. We found astrocytic atrophy in both the dentate gyrus and hippocampal CA1 field from middle age (12 months onwards). However, astroglial atrophy appears as a generalised process, astrocytes that surround neuritic plaques are clearly hypertrophic which suggest differential effects of AD on astroglial populations depending on their association with plaques which account for the progressive disruption of connectivity in neural networks and neurotransmitters imbalance which underlie cognitive impairments observed in AD.
Permanent Link: http://hdl.handle.net/11104/0189702