Neuroglia in neurodegeneration

0349466 - ÚEM 2011 RIV NL eng J - Journal Article
Heneka, M. T. - Rodríguez Arellano, Jose Julio - Verkhratsky, Alexei
Neuroglia in neurodegeneration.
Brain Research Reviews. Roč. 63, 1-2 (2010), s. 189-211. ISSN 0165-0173
R&D Projects: GA ČR GA309/09/1696; GA ČR GA305/08/1384
Institutional research plan: CEZ:AV0Z50390703
Keywords : Glia * Astrocyte * Microglia
Subject RIV: FH - Neurology
Impact factor: 8.842, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0349466_01.pdf

This is a very comprehensive review in which we tackle the fact that as Neuroglial cells are fundamental for control of brain homeostasis and they represent the intrinsic brain defence system; they are in consequence envolved in all forms in neuropathology; which is sustained by the evidence that neurodegenerative processes trigger universal and conserved glial reactions represented by astrogliosis and microglial activation. The complex of recently acquired knowledge allows us to regard the neurodegenerative diseases as primarily gliodegenerative processes, in which glial cells determine the progression and outcome of neuropathological disease
Permanent Link: http://hdl.handle.net/11104/0189699