Acid-sensing ion channels in rat hypothalamic vasopressin neurons of the supraoptic nucleus

0349379 - ÚEM 2011 RIV GB eng J - Journal Article
Ohbuchi, T. - Sato, K. - Suzuki, H. - Okada, Y. - Dayanithi, Govindan - Murphy, D. - Ueta, Y.
Acid-sensing ion channels in rat hypothalamic vasopressin neurons of the supraoptic nucleus.
Journal of Physiology. Roč. 588, č. 12 (2010), s. 2147-2162. ISSN 0022-3751. E-ISSN 1469-7793
Institutional research plan: CEZ:AV0Z50390703
Keywords : hypothalamus * ASIC * oxytocin
Subject RIV: FH - Neurology
Impact factor: 5.139, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0349379_01.pdf

Body fluid balance requires the release of vasopressin (AVP) from the neurohypophysis. Acid-sensing ion channels (ASICs) are neuronal voltage-insensitive cationic channels that are activated by extracellular acidification. We show that acid-induced ASIC current is enhanced by La- in isolated rat SON MNCs that express an AVP-eGFP transgene suggesting that interaction between ASICs and La- in the SON plays an important role in the regulatory mechanism of body fluid homeostasis
Permanent Link: http://hdl.handle.net/11104/0189635