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Differential Modulation of N-Type Calcium Channels by mu-Opioid Receptors in Oxytocinergic Versus Vasopressinergic Neurohypophysial Terminals

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    0349372 - ÚEM 2011 RIV US eng J - Journal Article
    Ortiz-Miranda, S. I. - Dayanithi, Govindan - Velazquez-Marrero, C. - Custer, E. E. - Treistman, S. N. - Lemos, J. R.
    Differential Modulation of N-Type Calcium Channels by mu-Opioid Receptors in Oxytocinergic Versus Vasopressinergic Neurohypophysial Terminals.
    Journal of Cellular Physiology. Roč. 225, č. 1 (2010), s. 276-288. ISSN 0021-9541. E-ISSN 1097-4652
    Institutional research plan: CEZ:AV0Z50390703
    Keywords : magnocellular neurons * G-protein modulation * neurohypophysis
    Subject RIV: FH - Neurology
    Impact factor: 3.986, year: 2010
    http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0349372_01.pdf

    Opioids modulate the electrical activity of magnocellular neurons (MCN) and inhibit neuropeptide release at their terminals in the neurohypophysis. We show that micro-opioid receptor (MOR) activation induces a stronger inhibition of oxytocin (OT) than vasopressin (AVP) release from isolated MCN terminals and found that N-type calcium channels in AVP terminals are differentially modulated by MOR.
    Permanent Link: http://hdl.handle.net/11104/0189629

     
     
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