Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation

0349342 - BTÚ 2011 RIV US eng J - Journal Article
Koudelka, S. - Mašek, J. - Neužil, Jiří - Turánek, J.
Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation.
Journal of Pharmaceutical Sciences. Roč. 99, č. 5 (2010), s. 2434-2443. ISSN 0022-3549. E-ISSN 1520-6017
R&D Projects: GA AV ČR(CZ) KAN200520703
Institutional research plan: CEZ:AV0Z50520701
Keywords : Vitamin E analogues * liposome * cancer
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 3.031, year: 2010

alpha-Tocopheryl succinate (alpha-TOS) is a semisynthetic analogue of alpha-tocopherol with selective toxicity to the cancer cells and anticancer activity in vivo. Yet, no suitable formulation of alpha-TOS for medical application has been reported. Various formulations, for example, solutions in organic solvents, oil emulsions and vesicules prepared by spontaneous vesiculation, polyethylene glycol conjugates and liposomes of various compositions have been tested. We developed and characterised a stable lyophilised liposome-based alpha-TOS formulation. alpha-TOS (15 mol%) was incorporated into large oligolamellar vesicles (OLVs) composed of soy phosphatidylcholine (SPC) by the method of lipid film hydration followed by extrusion through polycarbonate filters. The data indicate good physical and chemical stability of the lyophilised preparation of alpha-TOS liposomes that can be used in clinical medicine
Permanent Link: http://hdl.handle.net/11104/0189608