Effect of Feeding Status on Adjuvant Arthritis Severity, Cachexia, and Insulin Sensitivity in Male Lewis Rats

0349311 - ÚOCHB 2011 RIV GB eng J - Journal Article
Stofková, A. - Železná, Blanka - Romzová, Marianna - Uličná, O. - Kiss, A. - Skurlová, M. - Jurcovicová, J.
Effect of Feeding Status on Adjuvant Arthritis Severity, Cachexia, and Insulin Sensitivity in Male Lewis Rats.
Mediators of Inflammation. -, ID 398026 (2010), s. 1-12. ISSN 0962-9351. E-ISSN 1466-1861
R&D Projects: GA ČR GA305/06/0427; GA ČR GAP303/10/1368
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50520701
Keywords : adjuvant arthritis * feeding
Subject RIV: CE - Biochemistry
Impact factor: 2.059, year: 2010

We studied the effect of food restriction, overfeeding, and normofeeding on cachexia, inflammatory and metabolic parameters, and insulin sensitivity in chronic adjuvant arthritis (AA) in rats. Food restriction during AA increased circulating ghrelin, corticosterone, decreased leptin, and ameliorated arthrogram score and systemic inflammation compared to normofeeding. Overfeeding worsened arthrogram score and systemic inflammation, and led to lipid accumulation in the liver, but not to alterations of adipokine and ghrelin plasma levels relative to normofeeding. Independently of feeding status, AA induced cachexia, in which modulation of mRNA expressions for appetite-regulating neuropeptides (NPY, AgRP, POMC, CART) in the arcuate nucleus (ARC) does not play a primary role. The overexpression of IL-1beta mRNA in the ARC suggests its role in the mechanisms of impaired energy balance during AA under all feeding conditions.
Permanent Link: http://hdl.handle.net/11104/0189583