Effects of damage to auditory cortex on the discrimination of speech sounds by rats

0349290 - ÚEM 2011 RIV US eng J - Journal Article
Floody, O. R. - Ouda, Ladislav - Porter, B. A. - Kilgard, M. P.
Effects of damage to auditory cortex on the discrimination of speech sounds by rats.
Physiology and Behavior. Roč. 101, č. 2 (2010), s. 260-268. ISSN 0031-9384. E-ISSN 1873-507X
R&D Projects: GA ČR GA309/07/1336
Institutional research plan: CEZ:AV0Z50390703
Keywords : auditory cortex * brain lesions * prepulse inhibition
Subject RIV: FH - Neurology
Impact factor: 2.891, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0349290_01.pdf

The intensity of a noise-induced startle response can be reduced by the presentation of a stimulus immediately before the noise (“prepulse inhibition” or PPI). We used a form of PPI to study the effects of endothelin-induced damage to auditory cortex on the discrimination of human speech sounds by rats. The analysis of individual differences in performance by multiple regression suggests that some of the temporal processing required to discriminate speech sounds is concentrated anteroventrally in the right A1. These results also confirm that PPI can be adapted to studies of the brain mechanisms involved in the processing of speech and other complex sounds.
Permanent Link: http://hdl.handle.net/11104/0189567