Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Eschscholzia californica (Papaveraceae)

0349266 - ÚCHP 2011 RIV US eng J - Journal Article
Cahlíková, L. - Macáková, K. - Kuneš, J. - Kurfürst, Milan - Opletal, L. - Cvačka, Josef - Chlebek, J. - Blunden, G.
Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Eschscholzia californica (Papaveraceae).
Natural Product Communications. Roč. 5, č. 7 (2010), s. 1035-1038. ISSN 1934-578X. E-ISSN 1555-9475
Institutional research plan: CEZ:AV0Z40720504; CEZ:AV0Z40550506
Keywords : eschscholzia californica * papaveraceae * isoquinoline
Subject RIV: CI - Industrial Chemistry, Chemical Engineering
Impact factor: 0.894, year: 2010

The roots and aerial parts of Eschscholzia californica Cham. (Papaveraceae) were extracted with ethanol. Repeated column chromatography, preparative TLC, and crystallization led to the isolation of fourteen isoquinoline alkaloids, the structures of which were determined on the basis of spectroscopic techniques and by comparison with literature values. One of the compounds isolated, 1-(3-hydroxy-4-methoxybenzyl)-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline (14), has not previously been isolated from a natural source. All isolated compounds were tested for human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibition activity. None of the compounds isolated significantly inhibited both HuAChE and HuBuChE, but the two benzylisoquinoline alkaloids, reticuline 9 and 14, showed promising inhibitory activity against HuBuChE.
Permanent Link: http://hdl.handle.net/11104/0189553