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Synthesis of alpha-carboxyphosphinopeptides derived from norleucine
- 1.0349249 - ÚOCHB 2011 RIV AT eng J - Journal Article
Pícha, Jan - Buděšínský, Miloš - Fiedler, Pavel - Šanda, Miloslav - Jiráček, Jiří
Synthesis of alpha-carboxyphosphinopeptides derived from norleucine.
Amino Acids. Roč. 39, č. 5 (2010), s. 1265-1280. ISSN 0939-4451. E-ISSN 1438-2199
R&D Projects: GA ČR GA203/06/1405; GA MŠMT(CZ) LC06077
Institutional research plan: CEZ:AV0Z40550506
Keywords : phosphinate * phosphinic * pseudopeptide * inhibitor
Subject RIV: CC - Organic Chemistry
Impact factor: 4.106, year: 2010
In the present study, we describe in detail the synthesis of a relatively rare class of phosphorus compounds, a-carboxyphosphinopeptides. We prepared several norleucine-derived a-carboxyphosphinic pseudopeptides of the general formula Nle-[PO(OH)]-Gly. These compounds could find important applications as inhibitors of metalloaminopeptidases.
Permanent Link: http://hdl.handle.net/11104/0189540
Number of the records: 1