The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice

0349100 - BTÚ 2011 RIV ES eng C - Conference Paper (international conference)
Pěknicová, Jana - Elzeinová, Fatima - Nováková, Vendula - Buckiová, Daniela - Kubátová, Alena
The effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice.
Journal of Andrology - 9th International Congress of Andrology. Barcelona: The American Society, 2009 - (Wang, C.; Cortada, J.), s. 54-55. ISSN 0196-3635.
[9th International Congress of Andrology. Barcelona (ES), 07.03.2009-10.03.2009]
R&D Projects: GA MŠMT(CZ) 1M06011; GA MŠMT(CZ) 2B06151
Institutional research plan: CEZ:AV0Z50520701; CEZ:AV0Z50390703
Keywords : vinclozolin * spermatozoa * anti-androgen
Subject RIV: DN - Health Impact of the Environment Quality

The effect of a low dose of vinclozolin within the development of the reproductive tract during gestation (VIN-GD 15-22) and puberty (VIN-PND 23-44) in CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Sperm counts decreased to 46% (VIN-GD) and to 81% (VIN-PND), and also the acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to the control group (100%). Sperm head abnormalities increased by approximately 18% and 13%, respectively. In this connection, the expression of some genes was changed (arosome-related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, a low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups.
Permanent Link: http://hdl.handle.net/11104/0189429