The causes of cancer revisited: "Mitochondrial malignancy" and ROS-induced oncogenic transformation - Why mitochondria are targets for cancer therapy

0349092 - BTÚ 2011 RIV NL eng J - Journal Article
Ralph, S.J. - Rodruguez-Enriquez, S. - Neužil, Jiří - Saavedra, E. - Moreno-Sanchez, R.
The causes of cancer revisited: "Mitochondrial malignancy" and ROS-induced oncogenic transformation - Why mitochondria are targets for cancer therapy.
Molecular Aspects of Medicine. Roč. 31, č. 2 (2010), s. 145-170. ISSN 0098-2997. E-ISSN 1872-9452
Institutional research plan: CEZ:AV0Z50520701
Keywords : Carcinogenesis * mitocans * hypoxia
Subject RIV: FD - Oncology ; Hematology
Impact factor: 10.552, year: 2010

The review is organized into five sections concerning different aspects of "mitochondrial malignancy". The first concerns the functions of mitochondrial ROS and its importance as a pacesetter for cell growth versus senescence and death. The second considers the available evidence that cellular stress in the form of hypoxic and/or hypoglycaemic conditions represent two major triggering events for cancer and how oncoproteins reinforce this process. The third presents evidence that oncoproteins and tumor suppressor proteins physically localize to the mitochondria in cancer cells where they directly regulate malignant mitochondrial programs, including apoptosis. The fourth covers mutational changes in the mitochondrial genome as they relate to malignancy and to the other three areas. The last section concerns the relevance of these findings and their importance for novel approaches to anti-cancer therapy and selective triggering in cancer cells of the mitochondrial apoptotic pathway.
Permanent Link: http://hdl.handle.net/11104/0189422