Structures and Organelles in Pathogenic Protists Structures and Organelles in Pathogenic Protists

0349085 - BC 2011 RIV DE eng M - Monography Chapter
Lukeš, Julius - Hashimi, Hassan - Verner, Zdeněk - Číčová, Zdeňka
The Remarkable Mitochondrion of Trypanosomes and Related Flagellates.
Structures and Organelles in Pathogenic Protists Structures and Organelles in Pathogenic Protists. Heidelberg: Springer-Verlag Berlin, 2010 - (de Souza, W.), s. 228-252. Microbiology Monographs, 17. ISBN 978-3-642-12862-2
Institutional research plan: CEZ:AV0Z60220518
Keywords : Mitochondrion * flagellates
Subject RIV: EB - Genetics ; Molecular Biology

While the single mitochondrion of trypanosomatid flagellates contains many of the hallmarks that are known from mitochondria in other conventional model organisms, it also possesses several unique features, making it a subject of intense research. Here, we summarize current knowledge of the (1) structure, maintenance and replication of the extensive kinetoplastid DNA network, (2) byzantine organellar RNA metabolism, including insertion/deletion RNA editing, (3) translation of mitochondrial-encoded proteins, and, finally, (4) distinctive aspects of energy metabolism of the organelle. While we focus on the mitochondrion of Trypanosoma brucei, particularly in the context of its radical physiological and biochemical changes during the life cycle of the parasite, in order to get a more complete picture of the workings of this fascinating organelle, we also discuss significant findings obtained from other trypanosomatids.
Permanent Link: http://hdl.handle.net/11104/0189417