Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy

0349066 - ÚEM 2011 RIV GB eng J - Journal Article
Viero, C. - Shibuya, I. - Kitamura, N. - Verkhratsky, Alexei - Fujihara, H. - Katoh, A. - Ueta, Y. - Zingg, H. H. - Chvátal, Alexandr - Syková, Eva - Dayanithi, Govindan
Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy.
CNS Neuroscience & Therapeutics. Roč. 16, č. 5 (2010), e138-e156. ISSN 1755-5930. E-ISSN 1755-5949
R&D Projects: GA ČR GA309/08/1381; GA ČR GA305/08/1384; GA ČR GA309/09/1597; GA MŠMT(CZ) LC554
Grant - others:GA MŠk(CZ) 1M0538
Program: 1M
Institutional research plan: CEZ:AV0Z50390512
Keywords : ACTH * analgesics * behavior
Subject RIV: FH - Neurology
Impact factor: 3.492, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0349066_01.pdf

This review is focused on a small nine amino acid peptide, oxytocin, which is involved in a wide variety of physiological and pathological functions such as sexual activity, penile erection, ejaculation, pregnancy, uterus contraction, milk ejection, maternal behavior, osteoporosis, diabetes, cancer, social bonding, and stress, which makes oxytocin and its receptor potential candidates as targets for drug therapy. we address the issues of drug design and specificity and focus our discussion on recent findings on oxytocin and its heterotrimeric G protein-coupled receptor OTR.
Permanent Link: http://hdl.handle.net/11104/0189402