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Distinct effects of Sonic hedgehog and Wnt-7a on differentiation of neonatal neural stem/progenitor cells in vitro
- 1.0349062 - ÚEM 2011 RIV GB eng J - Journal Article
Prajerová, Iva - Honsa, Pavel - Chvátal, Alexandr - Anděrová, Miroslava
Distinct effects of Sonic hedgehog and Wnt-7a on differentiation of neonatal neural stem/progenitor cells in vitro.
Neuroscience. Roč. 171, č. 3 (2010), s. 693-711. ISSN 0306-4522. E-ISSN 1873-7544
R&D Projects: GA ČR GA305/09/0717; GA MŠMT(CZ) LC554
Grant - others:GA ČR(CZ) GD309/08/H079; GA MŠk(CZ) 1M0538
Program: 1M
Institutional research plan: CEZ:AV0Z50390512
Keywords : morphogen * potassium currents * sodium currents
Subject RIV: FH - Neurology
Impact factor: 3.215, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0349062_01.pdf
We explored the effect of two morphogens Sonic hedgehog and Wnt-7a on the proliferation, differentiation and membrane properties of neonatal neural stem/progenitor cells (NS/PCs) transduced with either Shh- or Wnt-7a. We found that Shh and Wnt-7a interfere differently with the process of neuronal differentiation and that they promote electrophysiologically and immunohistochemically distinct stages of neuronal differentiation in neonatal NS/PCs.
Permanent Link: http://hdl.handle.net/11104/0189399
Number of the records: 1