Analysis of In Vitro and In Vivo Characteristics of Human Embryonic Stem Cell-Derived Neural Precursors

0348933 - ÚEM 2011 RIV US eng J - Journal Article
Kozubenko, Nataliya - Turnovcová, Karolína - Kapcalová, Miroslava - Butenko, Olena - Anděrová, Miroslava - Rusňáková, Vendula - Kubista, Mikael - Hampl, Aleš - Jendelová, Pavla - Syková, Eva
Analysis of In Vitro and In Vivo Characteristics of Human Embryonic Stem Cell-Derived Neural Precursors.
Cell Transplantation. Roč. 19, č. 4 (2010), s. 471-486. ISSN 0963-6897. E-ISSN 1555-3892
R&D Projects: GA MŠMT(CZ) LC554; GA ČR GA305/09/0717
Grant - others:GA MŠk(CZ) 1M0538; EC FP6 project ENINET(XE) LSHM-CT-2005-019063; EC FP project STEMS(XE) LSHB-CT-2006-037328; GA AV ČR(CZ) IAA500520809; GA ČR(CZ) GD309/08/H079
Program: 1M; IA
Institutional research plan: CEZ:AV0Z50390703; CEZ:AV0Z50520701
Keywords : Human embryonic stem cells (hESCs) * Fluorescent-activated cell sorting * Neural differentiation
Subject RIV: FH - Neurology
Impact factor: 6.204, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0348933_01.pdf

In this article we demonstrate derivation and in vitro and in vivo (after transplantation in the rat model of stroke) analysis of highly enriched and expandable populations of proliferating neural precursors from hESCs. Our results complete the characterization of the CCTL14 line of hESCs and provide a framework for developing cell selection strategies for neural cell-based therapies.
Permanent Link: http://hdl.handle.net/11104/0189314