HPMA-RGD Hydrogels Seeded with Mesenchymal Stem Cells Improve Functional Outcome in Chronic Spinal Cord Injury

0348921 - ÚEM 2011 RIV US eng J - Journal Article
Hejčl, Aleš - Šedý, Jiří - Kapcalová, Miroslava - Arboleda Toro, David - Amemori, Takashi - Lesný, Petr - Likavčanová, Katarína - Krumbholcová, Eva - Přádný, Martin - Michálek, Jiří - Burian, M. - Hájek, M. - Jendelová, Pavla - Syková, Eva
HPMA-RGD Hydrogels Seeded with Mesenchymal Stem Cells Improve Functional Outcome in Chronic Spinal Cord Injury.
Stem Cells and Development. Roč. 19, č. 10 (2010), s. 1535-1546. ISSN 1547-3287. E-ISSN 1557-8534
R&D Projects: GA MŠMT(CZ) LC554; GA AV ČR IAA500390902
Grant - others:GA ČR(CZ) GD309/08/H079; GA MZd(CZ) 1A8697; GA MŠk(CZ) 1M0538; EC FP6 project RESCUE(XE) LSHB-CT-2005-518233
Program: 1M
Institutional research plan: CEZ:AV0Z50390703; CEZ:AV0Z40500505
Keywords : magnetic-resonance tracking * spinal cord injury * stem cells
Subject RIV: FH - Neurology
Impact factor: 4.791, year: 2010

In the November issue of the Stem Cells and Development journal, Hejčl et al. published a paper HPMA-RGD hydrogels seeded with mesenchymal stem cells improve functional outcome in chronic spinal cord injury. In the paper the authors evaluate implantation of hydrogels based on hydroxypropylmethacrylamide with attached amino acids (HPMA-RGD) seeded with mesenchymal stem cells (MSCs; therapy group I) in the therapy of experimental chronic spinal cord injury (SCI) in rats. They compare this therapy with either implantation of HPMA-RGD hydrogels (therapy group II) or SCI only (control group). The results show that implantation of HPMA-RGD hydrogels seeded with MSCs led to improved motor and sensory function of the hindlimbs of the rats and reduced atrophy of the spinal cord after 6 months,
Permanent Link: http://hdl.handle.net/11104/0189308