Long-circulating and passively tumor-targeted polymer-drug conjugates improve the efficacy and reduce the toxicity of radiochemotherapy

0348858 - ÚMCH 2011 RIV DE eng J - Journal Article
Lammers, T. - Šubr, Vladimír - Ulbrich, Karel - Peschke, P. - Huber, P. E. - Hennink, W. E. - Storm, G. - Kiessling, F.
Long-circulating and passively tumor-targeted polymer-drug conjugates improve the efficacy and reduce the toxicity of radiochemotherapy.
Advanced Engineering Materials. Roč. 12, č. 9 (2010), B413-B421. ISSN 1438-1656. E-ISSN 1527-2648
R&D Projects: GA MŠMT 1M0505
Institutional research plan: CEZ:AV0Z40500505
Keywords : HPMA copolymers * targeting * tumor targeting
Subject RIV: EI - Biotechnology ; Bionics
Impact factor: 1.746, year: 2010

Using HPMA copolymers as a model drug carrier, and doxorubicin and gemcitabine as model drugs, we here show that long-circulating and passively tumor-targeted polymeric drug carriers interact synergistically with radiotherapy, with radiotherapy improving the tumor accumulation of the copolymers, and with the copolymers improving both the efficacy and the toxicity of radiochemotherapy. These findings indicate that “carrier-based radiochemotherapy” holds significant potential for improving the treatment of advanced solid malignancies.
Permanent Link: http://hdl.handle.net/11104/0006063