Intrinsic nitric oxide-stimulatory activity of lipoteichoic acids from different Gram-positive bacteria

0348719 - ÚEM 2011 RIV NL eng J - Journal Article
Zídek, Zdeněk - Farghali, H. - Kmoníčková, Eva
Intrinsic nitric oxide-stimulatory activity of lipoteichoic acids from different Gram-positive bacteria.
Nitric Oxide-Biology and Chemistry. Roč. 23, č. 4 (2010), s. 300-310. ISSN 1089-8603. E-ISSN 1089-8611
R&D Projects: GA ČR GA305/08/0535
Institutional research plan: CEZ:AV0Z50390512
Keywords : Lipoteichoic acid * Gram-positive bacteria * Nitric oxide
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 3.384, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0348719_01.pdf

The cell wall of Gram-positive bacteria conain large amounts of lipoteichoic acid (LTA). We have found that LTA is endowed with immunostimulatory properties, the expression of which depends on its bacterial source. It has been demonstrated LTA shows positive response in Limulus amoebocyte assay (LAL), mimicking thus lipopolysaccharide (LPS) of Gram-negative bacteria. Similar to LPS, LTA binds to the antibiotics polymyxinB.
Permanent Link: http://hdl.handle.net/11104/0189162