Oligoperoxide based physically detectable nanocomposites for cell targeting, visualization and treatment

0348482 - ÚMCH 2011 RIV IT eng C - Conference Paper (international conference)
Zaichenko, A. S. - Mitina, N. - Shevchuk, O. - Shapoval, P. - Boiko, N. - Bilyy, R. - Stoika, R. - Voloshinovskii, A. - Horák, Daniel
Oligoperoxide based physically detectable nanocomposites for cell targeting, visualization and treatment.
AIP Conference Proceedings. Frascati: American Institute of Physics, 2010 - (Borsella, E.), s. 178-182. ISBN 978-0-7354-0826-5.
[BONSAI Project Symposium: Breakthroughs in Nanoparticles for Bio-Imaging. Frascati (IT), 08.04.2010-09.04.2010]
Institutional research plan: CEZ:AV0Z40500505
Keywords : oligoperoxide surfactants * oligoelectrolytes * drug and gene delivery systems
Subject RIV: CD - Macromolecular Chemistry

Novel promising routes for the obtaining luminescent, magnetic, plasmon resonance capable nanocomposites as well as drug delivery systems are proposed and studied. These routes are based on the synthesis and application of original type of functional oligoperoxides, their coordinating complexes of transition including rare earth metal cations for controlled synthesis of block, comb-like or nanogel oligoelectrolytes as well as for template synthesis of functional polymer and polymer-mineral nanoparticles. Developed nanoscale delivery systems were tested as medicines for cancer administration in vitro and in vivo. Physically detectable lectin-conjugated nanocomposites were studied as biomarkers for pathological cell targeting and visualization.
Permanent Link: http://hdl.handle.net/11104/0189009