Allosteric Modulation of Muscarinic Acetylcholine Receptors

0348428 - FGÚ 2011 RIV CH eng J - Journal Article
Jakubík, Jan - El-Fakahany, E. E.
Allosteric Modulation of Muscarinic Acetylcholine Receptors.
Pharmaceuticals. Roč. 3, č. 9 (2010), s. 2838-2860. E-ISSN 1424-8247
R&D Projects: GA ČR GA305/09/0681
Institutional research plan: CEZ:AV0Z50110509
Keywords : muscarinic acetylcholine receptors * allosteric modulation * Alzheimer´s disease
Subject RIV: CE - Biochemistry

This review summarizes over 30 years of reserch on the molecular mechanisms of allosteric interactions of drugs with the receptor and for new allosteric modulators of muscarinic receptors with potential therapeutic use. Identification of positive modulators of acetylcholine binding and function that enhance neurotransmission and the discovery of highly selective allosteric modulators are mile-stones on the way to novel therapeutic agents for the treatment of schizophrenia, Alzheimer´s disease and other involving impaired cognitive function
Permanent Link: http://hdl.handle.net/11104/0188969