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Factors enhancing L-valine production by the growth-limited L-isoleucine auxotrophic strain Corynebacterium glutamicum D-eltailvA D-panB ilvNM13 (pECKAilvBNC)
- 1.0348125 - MBÚ 2011 RIV DE eng J - Journal Article
Denina, I. - Paegle, L. - Prouza, Marek - Holátko, Jiří - Pátek, Miroslav - Nešvera, Jan - Ruklisha, M.
Factors enhancing L-valine production by the growth-limited L-isoleucine auxotrophic strain Corynebacterium glutamicum D-eltailvA D-panB ilvNM13 (pECKAilvBNC).
Journal of Industrial Microbiology & Biotechnology. Roč. 37, č. 7 (2010), s. 689-699. ISSN 1367-5435. E-ISSN 1476-5535
R&D Projects: GA ČR GC204/07/J012
Institutional research plan: CEZ:AV0Z50200510
Keywords : Corynebacterium glutamicum * L-valine synthesis * Limited growth
Subject RIV: EE - Microbiology, Virology
Impact factor: 2.416, year: 2010
The influence of stringent response on production of valine in recombinant strain of Corynebacterium glutamicum was tested. Increased production of valine was most probably caused by high activity of acetohydroxy acid synthase, the key enzyme of the biosynthesis of branched-chain amino acids. Positive effect of stringent response was shown in stationary growth phase due to maintaining high activity of acetohydroxy acid synthase and other enzymes of branched-chain amino acid biosynthesis
Permanent Link: http://hdl.handle.net/11104/0188735
Number of the records: 1