Hemoglobin adducts in 1,3-butadiene exposed Czech workers: Female–male comparisons

0347670 - ÚEM 2011 RIV IE eng J - Journal Article
Vacek, P. M. - Albertini, R. J. - Šrám, Radim - Upton, P. - Swenberg, J. A.
Hemoglobin adducts in 1,3-butadiene exposed Czech workers: Female–male comparisons.
Chemico-Biological Interactions. Roč. 188, č. 3 (2010), s. 668-676. ISSN 0009-2797. E-ISSN 1872-7786
Institutional research plan: CEZ:AV0Z50390512
Keywords : 3-Butadiene * metabolism * THB-Val hemoglobin adducts
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 2.832, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0347670_01.pdf

The results of this study confirm the findings of the previous molecular epidemiological study of female and male 1,3-butadiene (BD) exposed Czech workers, showing that females appeared to absorb or metabolize less BD per unit exposure conc. that did males (based on metabolite conc. in urine). In this study, another biomarker to measure a second metabolite of BD was used. The authors measured production and accumulation of the 1,2-dihydroxy-3,4-epoxybutane (EBD) metabolite as reflected in THB-Val hemoglobin adduct concentrations. In both the control and exposed groups mean THB-Val concentrations were significantly higher for males than females. It was also found that the size of difference increased with exposure.
Permanent Link: http://hdl.handle.net/11104/0188401