Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors

0347653 - ÚEM 2011 RIV US eng J - Journal Article
Mordukhovich, I. - Rössner ml., Pavel - Terry, M. B. - Santella, R. - Zhang, Y.J. - Hibshoosh, H. - Memeo, L. - Mansukhani, M. - Long, CH.M. - Garbowski, G. - Agrawal, M. - Gaudet, M. M. - Steck, S. E. - Sagiv, S. K. - Eng, S. M. - Teitelbaum, S. L. - Neugut, A. I. - Conway-Dorsey, K. - Gammon, M. D.
Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors.
Environmental Health Perspectives. Roč. 118, č. 4 (2010), s. 511-518. ISSN 0091-6765. E-ISSN 1552-9924
Institutional research plan: CEZ:AV0Z50390512
Keywords : breast cancer * p53 mutation * p53 overexpression
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 6.087, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0347653_01.pdf

The study tested the hypothesis that associations of PAH-related exposures with breast cancer differ according to tumor p53 mutation status, effect, type, and number. This possibility was examined in a population-based case-control study where p53 mutations in 859 tumors were detected. Participants with p53 mutations were less likely to be exposed to polycyclic aromatic hydrocarbons (PAHs) than participants without mutations. In conclusion, the study suggests that PAHs may be associated with specific breast tumor p53 mutation subgroup rather than with overall p53 mutations and may be related to breast cancer through mechanisms other than p53 mutation.
Permanent Link: http://hdl.handle.net/11104/0188386