NMDA receptor-dependent GABA(B) receptor internalization via CaMKII phosphorylation of serine 867 in GABA(B1)

0347602 - ÚEM 2011 RIV US eng J - Journal Article
Guetg, N. - Aziz, S. A. - Holbro, N. - Tureček, Rostislav - Rose, T. - Seddik, R. - Gassmann, M. - Moes, S. - Jenoe, P. - Oertner, T.G. - Casanova, E. - Bettler, B.
NMDA receptor-dependent GABA(B) receptor internalization via CaMKII phosphorylation of serine 867 in GABA(B1).
Proceedings of the National Academy of Sciences of the United States of America. Roč. 107, č. 31 (2010), s. 13924-13929. ISSN 0027-8424. E-ISSN 1091-6490
Grant - others:EU(XE) LSHM-CT-2005-019055
Institutional research plan: CEZ:AV0Z50390512
Keywords : gamma-aminobutyric acid * spines * trafficking
Subject RIV: FH - Neurology
Impact factor: 9.771, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0347602_01.pdf

We have found that NMDA receptor activation promotes dynamin-dependent endocytosis of GABA(B) receptors by Ca2+/Calmodulin-dependent protein kinase II (CaMKII) mechanism. CaMKII associates with GABA(B) in vivo and phosphorylates serine 867 (S867) in the intracellular C terminus of the GABA(B1) subunit. Time-lapse two-photon imaging of organotypic hippocampal slices reveals that activation of NMDA receptors removes GABA(B) receptors within minutes from the surface of dendritic spines and shafts. NMDA-dependent GABA(B) internalization is represents a novel form of synaptic plasticity
Permanent Link: http://hdl.handle.net/11104/0188349