A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer

0347498 - ÚEM 2011 RIV GB eng J - Journal Article
Campa, D. - Vodička, Pavel - Pardini, Barbara - Naccarati, Alessio - Carrai, M. - Vodičková, Ludmila - Novotný, J. - Hemminki, K. - Försti, A. - Barale, R. - Canzian, F.
A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer.
BMC Medical Genetics. Roč. 11, č. 1 (2010), s. 88-93. E-ISSN 1471-2350
R&D Projects: GA ČR GA310/05/2626
Institutional research plan: CEZ:AV0Z50390512
Keywords : colorectal cancer * TAS2R14
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.439, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0347498_01.pdf

Using a tagging approach we investigated all the common genetic variation of the gene region in relation to colon cancer risk with a case-control study design. This is, at the best of our knowledge also the first report on the allele frequencies of the gene in the Caucasian population. We found no evidence of statistically significant associations between polymorphisms in the TAS2R14 gene and colon cancer risk.
Permanent Link: http://hdl.handle.net/11104/0188270