Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility

0347490 - ÚEM 2011 RIV GB eng J - Journal Article
Lascors, J. - Försti, A. - Chen, B. - Buch, S. - Steinke, V. - Rahner, N. - Holinski-Feder, E. - Morak, M. - Schackert, H. K. - Görgens, H. - Schulmann, K. - Goecke, T. - Kloor, M. - Engel, C. - Büttner, R. - Kunkel, N. - Weires, M. - Hoffmeister, M. - Pardini, Barbara - Naccarati, Alessio - Vodičková, Ludmila - Novotný, J. - Schreiber, S. - Krawczak, M. - Bröring, C. D. - Völzke, H. - Schafmayer, C. - Vodička, Pavel - Chang-Claude, J. - Brenner, H. - Burwinkel, B. - Propping, P. - Hampe, J. - Hemminki, K.
Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility.
Carcinogenesis. Roč. 31, č. 9 (2010), s. 1612-1619. ISSN 0143-3334. E-ISSN 1460-2180
R&D Projects: GA ČR GA310/07/1430
Grant - others:EU(XE) HEALTH-F4-2007-200767
Institutional research plan: CEZ:AV0Z50390512
Keywords : colorectal cancer * gene ontology * confidence interval
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 5.402, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0347490_01.pdf

In this GWAs study, 10 664 genotyped single-nucleotide polymorphisms (SNPs) passed the quality control filtering in 371 German familial CRC patients and 1263 controls, and replication studies were conducted in four additional case-control sets (4915 cases and 5607 controls). We have observed that the risk of CRC increased significantly with an increasing number of risk alleles in seven genes involved in MAPK signalling events.
Permanent Link: http://hdl.handle.net/11104/0188262