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New bradykinin B-2 receptor antagonists - influence of C-terminal segment modifications on their pharmacological properties
- 1.0347364 - ÚOCHB 2011 RIV PL eng J - Journal Article
Sleszynska, M. - Kwiatkowska, A. - Sobolewski, D. - Wierzba, T. H. - Katarzynska, J. - Zabrocki, J. - Borovičková, Lenka - Slaninová, Jiřina - Prahl, A.
New bradykinin B-2 receptor antagonists - influence of C-terminal segment modifications on their pharmacological properties.
Acta Biochimica Polonica. Roč. 56, č. 4 (2009), s. 641-648. ISSN 0001-527X. E-ISSN 1734-154X
Institutional research plan: CEZ:AV0Z40550506
Keywords : bradykinin
Subject RIV: CC - Organic Chemistry
Impact factor: 1.262, year: 2009
Analogues of the bradykinin antagonist [D-Arg(0),Hyp(3),Thi(5,8),D-Phe(7)]BK having in position 7 or 8 L-pipecolic acid or L-beta(2)-isoproline or L-beta(3)-homoproline and free or acylated N-terminal amino group were synthesized and biologically evaluated (isolated rat uterus and rat blood pressure tests). The results thus support the hypothesis about the existence of different types of BK receptors in the rat uterus and blood vessels.
Permanent Link: http://hdl.handle.net/11104/0188157
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