Depletion of calcium stores contributes to progesterone-induced attenuation of calcium signaling of G protein-coupled receptors

0347353 - ÚOCHB 2011 RIV CH eng J - Journal Article
Gehrig-Burger, K. - Slaninová, Jiřina - Gimpl, G.
Depletion of calcium stores contributes to progesterone-induced attenuation of calcium signaling of G protein-coupled receptors.
Cellular and Molecular Life Sciences. Roč. 67, č. 16 (2010), s. 2815-2824. ISSN 1420-682X. E-ISSN 1420-9071
Institutional research plan: CEZ:AV0Z40550506
Keywords : non-genomic effect * oxytocin * bradykinin * progesterone
Subject RIV: CC - Organic Chemistry
Impact factor: 7.047, year: 2010

We demonstrated that within minutes, progesterone inhibits oxytocin- and bradykinin-induced contractions of rat uteri, calcium responses induced by platelet-activating factor in the human endometrial cell line MFE-280, and oxytocin-induced calcium signals in PHM1-31 immortalized pregnant human myometrial cells. Our data indicate that progesterone rapidly depletes intracellular calcium stores. The resulting desensitization of the cells might contribute to the quiescence of the uterus during pregnancy.
Permanent Link: http://hdl.handle.net/11104/0188148