Cyclodextrin-Based Bimodal Fluorescence/MRI Contrast Agents: An Efficient Approach to Cellular Imaging

0347324 - ÚEM 2011 RIV DE eng J - Journal Article
Kotková, Z. - Kotek, J. - Jirák, D. - Jendelová, Pavla - Herynek, V. - Berková, Z. - Hermann, P. - Lukeš, I.
Cyclodextrin-Based Bimodal Fluorescence/MRI Contrast Agents: An Efficient Approach to Cellular Imaging.
Chemistry - A European Journal. Roč. 16, č. 33 (2010), s. 10094-10102. ISSN 0947-6539. E-ISSN 1521-3765
R&D Projects: GA AV ČR(CZ) KAN201110651
Grant - others:EC FP6 project DiMI(XE) LSHB-CT-2005-512146; EC FP7 project ENCITE(XE) HEALTH-2007 A-201842; GA MŠk(CZ) GAUK 2007-B-Ch-132307
Institutional research plan: CEZ:AV0Z50390703
Keywords : mesenchymal stem-cells * marrow stromal cells * water exchange-rate
Subject RIV: CA - Inorganic Chemistry
Impact factor: 5.476, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0347324_01.pdf

A novel bimodal fluorescence/MRI probe based on a cyclodextrin scaffold has been synthesized and characterized. The agent is not cytotoxic and is easily internalized into cells. The labelled cells can be visualized by MRI, as proved by the detection of individual labelled pancreatic islets. A fluorescence study performed on mesenchymal stem cells showed that the agent stays in the intracellular space for a long time.
Permanent Link: http://hdl.handle.net/11104/0188126