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Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells
- 1.0347299 - BFÚ 2011 RIV IE eng J - Journal Article
Hrubá, E. - Trilecová, L. - Marvanová, S. - Krčmář, P. - Vykopalová, L. - Milcová, Alena - Líbalová, Helena - Topinka, Jan - Staršíchová, Andrea - Souček, Karel - Vondráček, Jan - Machala, M.
Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells.
Toxicology Letters. Roč. 198, č. 3 (2010), s. 227-235. ISSN 0378-4274. E-ISSN 1879-3169
Grant - others:GA ČR(CZ) GA310/07/0961
Program: GA
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50390512; CEZ:AV0Z50390703
Keywords : prostate epithelial cells * DNA adducts * carcinogenesis
Subject RIV: BO - Biophysics
Impact factor: 3.581, year: 2010
In the present study, we documented, for the first time, that although genotoxic PAHs produce significant levels of DNA adducts in the model of human prostate carcinoma cells, they do not activate the mechanisms leading to elimination of cells with significant DNA damage, presumably due to their failure to activate the p53-dependent DNA damage response.
Permanent Link: http://hdl.handle.net/11104/0188104
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