The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition

0347271 - BC 2011 RIV US eng J - Journal Article
Hada, K. - Asahina, Masako - Hasegawa, H. - Kanaho, Y. - Slack, F. J. - Niwa, R.
The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition.
Developmental Biology. Roč. 344, č. 2 (2010), s. 1100-1109. ISSN 0012-1606. E-ISSN 1095-564X
R&D Projects: GA ČR(CZ) GA204/07/0948; GA ČR(CZ) GD204/09/H058
Institutional research plan: CEZ:AV0Z60220518
Keywords : apl-1 * Caenorhabditis elegans * heterochronic gene * heterochronic gene * let-7 * nuclear receptor * nhr-25
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.094, year: 2010

Precise timing is essential for animal development. Its alteration, known as heterochrony, causes morphogenetic defects. Yet, little is known about the relationship between timing regulation and execution in terms of molecular action in the cell. Nuclear receptors play multiple roles in animal development, and NHR-25, an ancient member of the family, is involved in morphogenesis of various tissues of the worm C. elegans. We demonstrated that NHR-25 genetically interacts with the pathway of heterochronic genes including downstream targets of the let-7 microRNAs. NHR-25 together with the heterochronic genes modulates the timing of tissue-specific gene expression, cell fusion, cell division and cuticle formation. These data present the first example of a nuclear receptor interaction with the heterochrony pathway.
Permanent Link: http://hdl.handle.net/11104/0188082