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Tumor necrosis factor α sensitizes spinal cord TRPV1 receptors to the endogenous agonist N-oleoyldopamine
- 1.0347210 - FGÚ 2011 RIV GB eng J - Journal Article
Špicarová, Diana - Paleček, Jiří
Tumor necrosis factor α sensitizes spinal cord TRPV1 receptors to the endogenous agonist N-oleoyldopamine.
Journal of Neuroinflammation. Roč. 7, - (2010), s. 49-7. E-ISSN 1742-2094
R&D Projects: GA MŠMT(CZ) LC554; GA ČR GA305/09/1228
Institutional research plan: CEZ:AV0Z50110509
Keywords : TNF * TRPV1 * pain
Subject RIV: FH - Neurology
Impact factor: 5.785, year: 2010
In our experiments the possible influence of TNFa on presynaptic spinal cord TRPV1 receptor function was investigated. Our results indicate that TNFa may have a significant impact on nociceptive signaling at the spinal cord level that could be mediated by increased responsiveness of presynaptic TRPV1 receptors to endogenous agonists. This could be of major importance, especially during pathological conditions, when increased levels of TNFa and TNFR are present in the spinal cord
Permanent Link: http://hdl.handle.net/11104/0188038
Number of the records: 1