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Porphyrin-cyclodextrin conjugates as a nanosystem for versatile drug delivery and multimodal cancer therapy
- 1.0347154 - ÚMG 2011 RIV US eng J - Journal Article
Králová, Jarmila - Kejík, Z. - Bříza, T. - Poučková, P. - Kral, A. - Martásek, P. - Král, V.
Porphyrin-cyclodextrin conjugates as a nanosystem for versatile drug delivery and multimodal cancer therapy.
Journal of Medicinal Chemistry. Roč. 53, č. 1 (2010), s. 128-138. ISSN 0022-2623. E-ISSN 1520-4804
Institutional research plan: CEZ:AV0Z50520514
Keywords : photodynamic therapy * cancer therapy * porphyrin conjugate
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 5.207, year: 2010
The porphyrin-cyclodextrin conjugates were prepared and tested for selective and effective multi-functional drug delivery and therapy. The porphyrin receptor system combines efficient binding of the selected drug to the cyclodextrin cavity and photosensitizing properties of the porphyrin moiety with high accumulation of the whole complex in cancer tissue. The combined effect of chemotherapy and photodynamic therapy is demonstrated by in vitro and in vivo studies.
Permanent Link: http://hdl.handle.net/11104/0187994
Number of the records: 1