pH sensitive polymer nanoparticles: effect of hydrophobicity on self-assembly

0347038 - ÚMCH 2011 RIV US eng J - Journal Article
Filippov, Sergey K. - Starovoytova, Larisa - Koňák, Čestmír - Hrubý, Martin - Macková, Hana - Karlsson, G. - Štěpánek, Petr
pH sensitive polymer nanoparticles: effect of hydrophobicity on self-assembly.
Langmuir. Roč. 26, č. 18 (2010), s. 14450-14457. ISSN 0743-7463
R&D Projects: GA ČR GAP208/10/1600; GA AV ČR IAA100500501; GA ČR GPP207/10/P054; GA ČR GESON/06/E005
Institutional research plan: CEZ:AV0Z40500505
Keywords : complex * hydrophobicity * surfactant
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 4.269, year: 2010

For the first time, we have described the detailed mechanism of the formation of pH-sensitive nanoparticles with varying pH using dynamic information from NMR, charge properties from zeta-potential, aggregation behavior from light scattering, and particle imaging using cryo-TEM. We have shown that, at basic conditions, a polymer-surfactant complex with pearl-necklace structure exists. At lower pH, globulized complexes occur due to coil-to-globule transition of a polyanion. With a further decrease of pH, the globulized complexes assemble into larger nanoparticles that are stabilized by streric repulsion of hydrophilic PEO chains of the surfactant.
Permanent Link: http://hdl.handle.net/11104/0006003