P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes

0346838 - ÚMG 2011 RIV US eng J - Journal Article
Flemr, Matyáš - Ma, J. - Schultz, R. M. - Svoboda, Petr
P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes.
Biology of Reproduction. Roč. 82, č. 5 (2010), s. 1008-1017. ISSN 0006-3363. E-ISSN 1529-7268
R&D Projects: GA MŠMT ME09039
Grant - others:EMBO SDIG(DE) project 1483
Institutional research plan: CEZ:AV0Z50520514
Keywords : oocyte * mRNA * cortex
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.870, year: 2010

P-bodies are centers of mRNA metabolism, where meet pathways linked to mRNA silencing and degradation. So far, P-bodies were found in all examined mammalian cells.Here, we show an unexpected and important discovery that P-bodies disappear from oocztes at the beginning of their growth phase and appear again only in the early embryo. P-body decay likely reflects the requirement stabiliyation and storage of maternal mRNAs, which will govern development until the zygotc expression takes over. In addition, we were the first to show that stored maternal mRNAs do not have a homogeneous distribution. Instead, they localize to the periphery – cortex.
Permanent Link: http://hdl.handle.net/11104/0187756