MicroRNA activity is suppressed in mouse oocytes

0346835 - ÚMG 2011 RIV GB eng J - Journal Article
Ma, J. - Flemr, Matyáš - Stein, P. - Berninger, P. - Malík, Radek - Zavolan, M. - Svoboda, Petr - Schultz, R.M.
MicroRNA activity is suppressed in mouse oocytes.
Current Biology. Roč. 20, č. 3 (2010), s. 265-270. ISSN 0960-9822. E-ISSN 1879-0445
R&D Projects: GA ČR GAP305/10/2215; GA MŠMT ME09039
Grant - others:EMBO SDIG(DE) project 1483
Institutional research plan: CEZ:AV0Z50520514
Keywords : miRNA * oocyte * pluripotency
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 10.025, year: 2010

Research article describing miRNA pathway analysis, which showed that miRNAs are normally produced but their activity is suppressed. This is a surprising and important discovery in the field of pluripotent stem cells because mikroRNAs are required for defining the cellular identity and their absence in the oocyte suggests a ling to the later establishment of pluripotency.
Permanent Link: http://hdl.handle.net/11104/0187754