The role of miRNAs and endogenous siRNAs in maternal-to-zygotic reprogramming and the establishment of pluripotency

0346834 - ÚMG 2011 RIV GB eng J - Journal Article
Svoboda, Petr - Flemr, Matyáš
The role of miRNAs and endogenous siRNAs in maternal-to-zygotic reprogramming and the establishment of pluripotency.
Embo Reports. Roč. 11, č. 8 (2010), s. 590-597. ISSN 1469-221X. E-ISSN 1469-3178
R&D Projects: GA ČR GA204/09/0085; GA ČR GAP305/10/2215; GA MŠMT ME09039
Grant - others:EMBO SDIG(DE) project 1483
Institutional research plan: CEZ:AV0Z50520514
Keywords : RNAi * miRNA * pluripotency
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 7.822, year: 2010

A review article discussing roles of RNA silencing in establishment and maintenance of pluripotency. A significant part of the transition of an oocyte into pluripotent cells of the embryo occurs in the absence of transcription. Therefore, post-transcriptional mechanisms (including RNA silencing) are important for proper reprogramming and establishment of pluripotency. The article is summarizing current data and is discussing possible roles of RNA silencing in establishment and maintenance of pluripotency.
Permanent Link: http://hdl.handle.net/11104/0187753