The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus

0346801 - BFÚ 2011 RIV GB eng J - Journal Article
Andrysík, Zdeněk - Bernstein, W.Z. - Deng, L. - Myer, D.L. - Li, Y.-Q. - Tischfield, J.A. - Stambrook, P.J. - Bahassi, E.M.
The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus.
Nucleic Acids Research. Roč. 38, č. 9 (2010), s. 2931-2943. ISSN 0305-1048. E-ISSN 1362-4962
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : Polo * DNA damage * Plk5
Subject RIV: BO - Biophysics
Impact factor: 7.836, year: 2010

Here, we report the cloning of a fifth member of the Polo-like kinase family named Plk5. We show that mouse Plk5 is a DNA damage inducible gene. Ectopic expression of Plk5 leads to cell cycle arrest in G1, decreased DNA synthesis, and to apoptosis. Interestingly, in contrast to mouse Plk5 gene, the sequence of human Plk5 contains a stop codon that produces a truncated protein lacking part of the kinase domain.
Permanent Link: http://hdl.handle.net/11104/0187727