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Immunoregulatory properties of mouse limbal stem cells
- 1.0346785 - ÚMG 2011 RIV US eng J - Journal Article
Holáň, Vladimír - Pokorná, Kateřina - Procházková, Jana - Krulová, M. - Zajícová, Alena
Immunoregulatory properties of mouse limbal stem cells.
Journal of Immunology. Roč. 184, č. 4 (2010), s. 2124-2129. ISSN 0022-1767. E-ISSN 1550-6606
R&D Projects: GA AV ČR KAN200520804; GA MŠMT 1M0506; GA ČR GD310/08/H077
Institutional research plan: CEZ:AV0Z50520514
Keywords : Limbal stem cells * immunoregulation * apoptosis
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 5.745, year: 2010
We isolated a highly purified population of mouse limbal stem cells. These cells expressed immunosuppressive and immunoregulatory properties. In addition, limbal stem cells had a high expression of genes for the anti-apoptotic molecules Bcl-1, XIAP and Survivin and for Fas ligand, and displayed an enhanced resistence to the apoptosis-inducing agents and to cell-mediated immunity. The results thus showed novel undescribed properties of adult stem cells. These immunoregulatory and self-protecting properties of adult tissue specific stem cells can be responsible for protection of stem cells which have a vital role in reparation and regeneration of tissues and organs.
Permanent Link: http://hdl.handle.net/11104/0187714
Number of the records: 1