Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells

0346779 - ÚMG 2011 RIV US eng J - Journal Article
Lettau, I. - Hattermann, K. - Held-Feindt, J. - Brauer, Rena - Sedláček, Radislav - Mentlein, R.
Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells.
Journal of Neuropathology and Experimental Neurology. Roč. 69, č. 3 (2010), s. 215-223. ISSN 0022-3069. E-ISSN 1554-6578
Institutional research plan: CEZ:AV0Z50520514
Keywords : extracellular matrix * MMP-28 * keratinocytes
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.190, year: 2010

Glial tumors exhibit a high morbidity and mortality because of their invasive nature. Matrix metalloproteinase 19 (MMP19) is a secreted protease that together with epilysin (MMP28) forms a structural subgroup of MMPs. In contrast, MMP19 was detected in normal brain samples only in endothelial cells but was found at high levels in astrocytomas. MMP19 was upregulated in GB cells after exposure to proinflammatory cytokines. MMP19-silenced cells migrated more slowly through laminin-, basal lamina-, and brevican-coated membranes than controls. MMP19-silenced GB cells also migrated into brain tissue slices compared with control cells. Brevican, a brain-specific proteoglycan and major component of brain extracellular matrix, was degraded by recombinant human MMP19. MMP19 is highly expressed in proliferating astrocytoma/glioma cells and its expression may facilitate their invasion through brain extracellular matrix
Permanent Link: http://hdl.handle.net/11104/0187710