Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro

0346777 - BTÚ 2011 RIV US eng J - Journal Article
Čtrnáctá, Vlasta - Fritzler, J. M. - Šurínová, M. - Hrdý, I. - Zhu, G. - Stejskal, F.
Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro.
Experimental Parasitology. Roč. 126, č. 2 (2010), s. 113-116. ISSN 0014-4894. E-ISSN 1090-2449
Institutional research plan: CEZ:AV0Z50520701
Keywords : S-adenosylhomocysteine hydrolase * D-eritadenine * (S)-DHPA
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 1.869, year: 2010

D-eritadenine and (S)-DHPA are aliphatic adenosine analogues known to target S-adenosylhomocysteine hydrolase (SAHH) and potent antiviral compounds. In the present study, we demonstrate that these two compounds also display efficacy against recombinant SAHH enzyme of the protozoan parasite Cryptosporidium parvum, as well as inhibition of parasite growth in vitro. Our data confirm that SAHH could serve as a rational drug target in cryptosporidial infection and antiviral adenosine analogues are potential candidates for drug development against cryptosporidiosis
Permanent Link: http://hdl.handle.net/11104/0187708