Raman spectroscopic study on sodium hyaluronate: an effect of proton and gamma irradiation

0346760 - ÚJF 2012 RIV GB eng J - Journal Article
Synytsya, A. - Alexa, P. - Wagner, Richard - Davídková, Marie - Volka, K. … Total 6 authors
Raman spectroscopic study on sodium hyaluronate: an effect of proton and gamma irradiation.
Journal of Raman Spectroscopy. Roč. 42, č. 3 (2011), s. 544-550. ISSN 0377-0486. E-ISSN 1097-4555
Institutional research plan: CEZ:AV0Z10480505
Keywords : sodium hyaluronate * proton irradiation * gamma irradiation * Raman spectroscopy
Subject RIV: CB - Analytical Chemistry, Separation
Impact factor: 3.087, year: 2011
http://onlinelibrary.wiley.com/doi/10.1002/jrs.2724/full

Raman spectroscopy was applied to the analysis of structural changes in lyophilised sodium hyaluronate after proton and gamma irradiation (0.5, 5, 50, 100, 200 and 600 Gy). Characteristic Raman bands of the polysaccharide were sensitive to irradiation. Significant damage was observed at doses of 50 Gy or higher. The spectral changes confirmed radiation-induced loss of native solution conformation, destruction of primary structure, fragmentation, cross-linking and elimination of functional groups. Differences in the effects of proton and gamma radiation on sodium hyaluronate are discussed.
Permanent Link: http://hdl.handle.net/11104/0187695