Biodistribution of a radiolabelled thermoresponsive polymer in mice

0346494 - ÚJF 2011 RIV GB eng J - Journal Article
Kučka, Jan - Hrubý, Martin - Lebeda, Ondřej
Biodistribution of a radiolabelled thermoresponsive polymer in mice.
Applied Radiation and Isotopes. Roč. 68, č. 6 (2010), s. 1073-1078. ISSN 0969-8043
R&D Projects: GA ČR GPP207/10/P054; GA MŠMT 2B06165
Institutional research plan: CEZ:AV0Z10480505; CEZ:AV0Z40500505
Keywords : Thermoresponsive polymer * I-131 * Local radiotherapy
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 0.999, year: 2010

Drug delivery systems based on thermoresponsive polymers might serve as suitable carriers for local radiotherapy. We have, therefore, designed and synthesized a radioiodine-labellable thermoresponsive polymer. The polymer was synthesized by copolymerization of N-isopropylacrylamide with N-methacryloyl tyrosinamide in tetrahydrofuran, and then labelled by I-131. The solution of this labelled polymer in dimethylsulfoxide (4.4 MBq/ml; 1.8 wt% polymer) was applied to femoral muscle of male Balb/C mice (50 mu l per animal). The biodistribution and excretion of radioactivity was followed in 2 h and 1, 7, 14, 28 and 42d post injection (n=6 per time point).
Permanent Link: http://hdl.handle.net/11104/0005984