Cathepsins B1 and B2 in the neuropathogenic schistosome Trichobilharzia regenti: distinct gene expression profiles and presumptive roles throughout the life cycle

0346460 - ÚBO 2011 RIV DE eng J - Journal Article
Dolečková, K. - Albrecht, Tomáš - Mikeš, L. - Horák, P.
Cathepsins B1 and B2 in the neuropathogenic schistosome Trichobilharzia regenti: distinct gene expression profiles and presumptive roles throughout the life cycle.
Parasitology Research. Roč. 107, č. 3 (2010), s. 751-755. ISSN 0932-0113. E-ISSN 1432-1955
R&D Projects: GA MŠMT LC06073
Institutional research plan: CEZ:AV0Z60930519
Keywords : Cathepsin * Schistosome * Trichobilharzia * Helminth * Neuropathogen
Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine
Impact factor: 1.812, year: 2010

Real-time polymerase chain reaction was used to characterize the temporal distribution of transcripts of two cathepsins in different developmental stages of Trichobilharzia regenti: cathepsin B1 originally described from the gut lumen of schistosomula with presumptive role in nutrient digestion and cathepsin B2 originally found in penetration glands of cercariae with probable involvement in invasion of the final host. The mRNA expression profiles clearly show distinct expression of cathepsins B1 and B2 during the development from eggs to cercariae. In the case of both cathepsins, the highest level of transcription was detected in intravertebrate stages.
Permanent Link: http://hdl.handle.net/11104/0187484